Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4 		0.010 AlteredExpression disease BEFREE Cytoprotection achieved with IL-4 and IL-13 is mediated by the early activation of signal transducer and activator of transcription 6 (STAT6) in beta cells, leading to the upregulation of anti-apoptotic proteins, including myeloid leukaemia-1 (MCL-1) and B cell lymphoma-extra large (BCLXL). 30338340 2019
Entrez Id: 6778
Gene Symbol: STAT6
STAT6 		0.010 AlteredExpression disease BEFREE Cytoprotection achieved with IL-4 and IL-13 is mediated by the early activation of signal transducer and activator of transcription 6 (STAT6) in beta cells, leading to the upregulation of anti-apoptotic proteins, including myeloid leukaemia-1 (MCL-1) and B cell lymphoma-extra large (BCLXL). 30338340 2019
Entrez Id: 406935
Gene Symbol: MIR143
MIR143 		0.010 Biomarker disease BEFREE MiR-143 regulates proliferation and apoptosis of myelocytic leukemia cell HL-60 via modulating ERK1. 29917183 2018
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.010 Biomarker disease BEFREE MiR-143 regulates proliferation and apoptosis of myelocytic leukemia cell HL-60 via modulating ERK1. 29917183 2018
Entrez Id: 23326
Gene Symbol: USP22
USP22 		0.010 Biomarker disease BEFREE USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism. 29844011 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.020 Biomarker disease BEFREE It was found that MiR-21 was found to be normally upregulated in all types of ML, however, we summarize the important research findings surrounding the role of miR-21 in different types of ML. 29795410 2018
Entrez Id: 652995
Gene Symbol: UCA1
UCA1 		0.010 AlteredExpression disease BEFREE We found that lncRNA UCA1 was upregulated in ML cell lines. 29762824 2018
Entrez Id: 28951
Gene Symbol: TRIB2
TRIB2 		0.020 Biomarker disease BEFREE A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. 29670085 2018
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.020 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 1398
Gene Symbol: CRK
CRK 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 9402
Gene Symbol: GRAP2
GRAP2 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 25897
Gene Symbol: RNF19A
RNF19A 		0.010 AlteredExpression disease BEFREE Our data provide evidence for a tumour suppressor role of Trib2 in myeloid leukaemia via activation of p38 stress signalling. 29670085 2018
Entrez Id: 9232
Gene Symbol: PTTG1
PTTG1 		0.020 Biomarker disease BEFREE Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein. 29649138 2018
Entrez Id: 1977
Gene Symbol: EIF4E
EIF4E 		0.010 Biomarker disease BEFREE The role of eIF4E in myeloid leukemia has been ascertained and drugs targeting its functions have found their place in clinical trials. 29527921 2018
Entrez Id: 643911
Gene Symbol: CRNDE
CRNDE 		0.010 AlteredExpression disease BEFREE Results of clinical data showed that the expression of lncRNA-CRNDE was associated with the classification and total survival of myeloid leukemia in clinical patients. 29461608 2018
Entrez Id: 861
Gene Symbol: RUNX1
RUNX1 		0.100 GeneticVariation disease BEFREE Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors. 29438697 2018
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.010 Biomarker disease BEFREE Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors. 29438697 2018
Entrez Id: 11009
Gene Symbol: IL24
IL24 		0.030 Biomarker disease BEFREE In this study, we investigated the role of IL-24 in immunogenicity modulation of the myelogenous leukemia cells. 29420334 2018
Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2 		0.010 Biomarker disease BEFREE Silencing of HMGA2 reverses retardance of cell differentiation in human myeloid leukaemia. 29384529 2018
Entrez Id: 27352
Gene Symbol: SGSM3
SGSM3 		0.010 AlteredExpression disease BEFREE Importantly, by querying the connectivity MAP using up- and downregulated genes that are present exclusively in NIK-stabilized LSCs, we discovered that verteporfin has anti-AML effects, suggesting that repurposing verteporfin to target myeloid leukemia is worth testing clinically. 29320732 2018
Entrez Id: 4602
Gene Symbol: MYB
MYB 		0.020 Biomarker disease BEFREE MYB-driven transcriptional coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and myeloid leukemias, including refractory MLL-rearranged leukemias. 29317678 2018